ie, does it enhance or intensity the effects? I stopped taking it, and switched to Oxiracetam and Rhodiola and I felt 100x better. This includes improving and enhancing the body’s response to insulin. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. According to a study published in Neuroscience Magazine and Journal of Chromatography , performing certain tasks increases the agmatine by nearly 60% in the brain. Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. It works directly, and the effects persists after use. (I don't find it energising, but not sedative either at my dosage). That said, little research has been done on what the appropriate dosage should be. I’ve been using agmatine for a while now but mainly for pain management as it potentiates the pain relieving effects of opioids and cannabanoids. share. The B-Complex shouldn't (I'm not a professional) cause any interaction, but again, consult with the professional. https://www.reddit.com/r/Nootropics/comments/7ezn7q/substances_that_share_the_same_moa_as_ketamine/. Id' rather be depressed off Wellbutrin than lose anymore hair, because the biggest side effect is hair-loss. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. Agmatine is quickly replacing arginine as the go-to nitric oxide ingredient. Can you explain further. Press question mark to learn the rest of the keyboard shortcuts. Looks like you're using new Reddit on an old browser. I took 1g with 45mg of Nardil for a few weeks, no issues. Placebo or not I an damn happy with how I reacted. Yes, always take a B-complex. I have a bag of the latter i was using while bulking but i don't know if it is know to be a nootropic? Potential Benefits of Agmatine. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. As someone else stated, agmatine is awesome. That gave me 1g of Agmatine + 5g of citruline malate. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. I hated the Wellbutrin. I take it at night as I thought it was supposed to help with sleep. I'm deleting my 1.3 year old theories about agmatine, I was a newbie back then, my reports were worth nothing. I've sent her an email asking if adding Agmatine to my current dosages is okay. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatm … I've been through some of the posts, but would like to know of others experience with it. Agmatine as punchy as Ketamine for depression - posted in Mental Health: Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. This is due to its positive impact on the nervous system. 3 comments. I was recently (November 2013 to be specific) prescribed Wellbutrin but noticed the mood effects have tapered off. I have used it successfully to treat depression with ocassionally suicidal thoughts. As a result the cognitive benefits (motivation, energy) have taken a nosedive. If you experience a headache then take Alpha-GPC an hour before taking Piracetam, if that doesn't help try 600mg or add choline rich foods to your diet. In the excitement to learn all about agmatine’s muscle building benefits, however, the side effects conversation is usually tabled and never revisited. I have created a post about in the nootropics area along with other substances that share the same effect pharmalogical profile on the brain as ketamine and agmatine have. So I emailed my doc and asked to go back on the full dose, which she said was fine for the time and maybe we could consider lowering at another point in my life. Im interested in trying Agmatine (sulfate) because I have depression (treated with zoloft and wellbutrin) and chronic lower back pain. Most human-based testing has utilized 2.6 grams per day or slightly higher. Wellbutrin is an antidepressant that may be used to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). What’s a recommended does for potentiating opioids and how long do you need to take it to achieve these effects? There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. It can be found in fermented foods because it is a bacterial byproduct. This sub is not for venting or for facebook style posts. and do not have the psychedelic side effects such as ketamine. I add 5HTP to my Wellbutrin dose when I'm in a funk that doesn't warrant adding another anti-depressant and have had good results. I’ve read it’s also a supplement for weight training. I'm writing this on my phone so excuse my writing :). otherwise I've done 2 scoops of Iforce Hemavol and that worked great. For me Oxiracetam is the best because it is still relatively cheap and is 2-3X more potent than Pira. Before bed I take a 100mg 5HTP/1,000mg B6 complex. Discussion and anecdotes are welcome! Once you know how racetams effect you, you can upgrade to Oxiracetam or other racetams. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. Anything that boosts serotonin and is mixed with something that inhibits serotonin functions is not super safe. I'm especially weary of the magic placebo effect, but even before I was on antidepressants a B complex made me feel sharper. Are Agmatine and "agmatine sulfate" the same? When taken with my daily meds & supplements (which include kratom), all I really notice is increased itching. [1] [2] Clinical research involving agmatine is scarce, but many athletic professionals and scientific researchers promote agmatine as a safe, reliable sports enhancement supplement. Those who have used this, where did you purchase yours? Agmatine is considered to be a neurotransmitter and neuromodulator. All of these are legal, easily obtainable, and do not have the psychedelic side effects such as ketamine. 100-200mg for anti-fatigue, 300-600mg for anti-stress, anti-anxiety. I have found it to work really well. Thanks. Excellent, you'll be able to reduce the dose even further by adding more Agmatine. In the brain Agmatine does not directly convert into Nitric Oxide like L Arginine does. Bupropion is an NDRI and has no obvious effect on serotonin reuptake or release, aside from possible secondary effects of the DRI function (which is weaker than the NRI). Here is my usual suggestion. report. Moderate dosages, though slightly less potent that depression drugs such as Tofranil (imipramine), show a promising ability to improve mood and reduce anxiety. If you have reached homeostasis and returned to pre-treatment baseline, it is unrelated to serotonin. Low quality posts will be removed. This study investigated the effects of the combined administration of agmatine with either conventional monoaminergic antidepressants or the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 in the tail suspension test (TST) in mice. Hemavol tastes great too - … You can read my personal testimony to it there, it is very powerful. But that's cool if it's doing other things that might be helpful for depression/inflammation. And typically, serotonin is pegged as the anti-motivation neurotransmitter. Press question mark to learn the rest of the keyboard shortcuts. Agmatine is an endogenous amine synthesized via the decarboxylation of L-arginine mediated by arginine decarboxylase. save. Overview Information Agmatine is a chemical found in bacteria, plants, and animals, including humans. Does Agmatine work synergistically with Wellbutrin XL? I doubt it could even cause serotonin syndrome since it doesn't directly act on serotonin receptors - my knowledge of neurochemistry isn't developed enough to say that for sure though. I don’t think you understand the definition of side effect. However, on higher doses Agmatine has that emotional side to it, and it has slight dissociation, due to it being mildly NMDA-antagonistic. Research has found agmatine to be non-toxic when taken appropriately. Hello all, I'm new to nootropics and had a quick question. It was noticeable after a couple of days. I didn't rage- which felt totally out of character for me. “Started Wellbutrin 150 three years ago for depression, worked great, lost about 15 pounds in 6 months. I’ve read it does potentiate opioids and so on and also lowers tolerance. Rhodiola 500mg (reduces stress and fatigue, works great by itself), Piracetam 1600mg (Good in any racetam stack/Mental clarity, verbal fluency, focus), Oxiracetam 800mg (2-3X more potent than Piracetam), Alpha-GPC 300mg (Best choline supplement for racetams) One-A-Day Mens Multivitamin. Also, Rhodiola Rosea works great by itself. It takes two weeks to start feeling the full effects of Pira. Modafinil comes with absolutely no pleasant feelings for me, it just puts me in this zone. Facebook Twitter LinkedIn Tumblr Pinterest Reddit WhatsApp. Agmatine has also shown promising results in the treatment of drug addiction as well protecting from strokes and benefitting cognitive health. Preliminary googling looks like it helps boost serotonin. But being on only 150 mg of Wellbutrin was really not doing my brain very well at all - brain fog, headaches, not wanting to get out of bed. [127] Depression also appears to be associated with perturbed imidazoline receptor signalling. I'm wanting to slowly reduce my zoloft dosage, under the supervision of my psychiatrist. I have loss 1/3 of my hair, and enough was enough. It works synergistically with numerous antidepressants. The efficacy of Wellbutrin in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. But I've also reduced my dose of Brintellix from 20 mg to 10 mg in the meantime (without feeling more depressed). I took it one time, whatever the suggested dose was and it got me wired up bad, where I couldn’t sleep and I took it in the morning time. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. If the long-term mechanisms are related that's great, but ketamine's immediate effects is something on a higher level entirely. Introduction. Key Takeaways. Been on it three weeks (100mgs the first week, then 200mgs the second week, finally 300mgs) and it hasn't seemed to help the depression. After taking both Moda and Agmatine together the effects of Modafinil seem different, in a good way. Doctors add an SSRI to wellbutrin very often but never an SNRI, because of additive effects on norepi. Rhodiola off Amazon, the NOW brand. It is made from the amino acid known as arginine. "Agmatine is also influenced by pharmaceutical depressants, being reduced in concentration by bupropion (Wellbutrin)[69] while SSRI drugs increase agmatine concentrations. I was upped to the 300mg Bupropin XL (of dubious bioequivalence) and after experiencing withdrawal symptoms, determined that serotonin reuptake may not be the issue at hand. Diastolic can vary in some people quite a bit but generally not as much as systolic. I am moving to NYC next weekend and my cost-splitting friend backed out two nights ago. What Is Agmatine? On its own, Agmatine does not induce the effects typical of a “high.” Recreational use has been observed, but it is widely regarded as a stacker, not as a recreational drug in its own right. From novel/alternative substances, to established medications. It is stored in neurons and is released during neuronal activation. You doctor chose not to. (450 mg x 7 times a week is actually slightly more than your weekly 2,6 g). Dosage is up to 2.6 grams. Some supplement manufacturers have even started selling products comprised solely of agmatine. Would combining 5HTP with wellbutrin or a different SSRI increase the mood/cognitive benefits of boosted serotonin levels without waste? Whuuuuut? Try that for a few days. admin 2 hours ago. Unlike Kratom, Agmatine is an amino acid compound, which is also produced by our bodies. Being disentangled from the fabric of reality can be very therapeutic. Agmatine is synthesized in the brain, kidney, liver, adrenal gland, macrophages and small intestine. I buy my noot powders from NootropicsDepot. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. Agmatine Sulfate also provides a number of athletic benefits. Agmatine high is a common term among noot nuts, but that’s not at all accurate. Contrary to popular belief, Agmatine is not as … I have a big bag of agmatine in my drawer! New comments cannot be posted and votes cannot be cast, More posts from the StackAdvice community, Press J to jump to the feed. Coupled up with Kratom, Agmatine helps combat chronic conditions to provide lasting tranquility. The Definitive Guide to Agmatine Sulfate Supplementation. Bulksupplements is the cheapest and best. Agmatine is one of the most fascinating, and beneficial, substances. I suppose they have a preset cookie cutter flowchart. New comments cannot be posted and votes cannot be cast. It's not a side effect, it's what makes ketamine awesome. I am on Wellbutrin 100mg 3x a day. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). Thanks! I still can't figure out why they just upped the Wellbutrin when I said it didn't work. This thread is archived. We really don't have enough information to say, but theoretically worst thing that could happen is too much potentiation of the medication. No. Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). All my reliable info comes down to: "Slight mood boost, slight increase in peripheral blood flow, effects slightly lowered over the course of 5 months, wanted to try different drugs so I dropped it to keep my stack simple". 750mg is my dose. I hope this helps, and I'll answer any questions. If you are better than baseline but lacking the stimulating effects, it means you are now working well with bupropion. I take it once a week to save on cost rather than taking it daily. I would like to buy a good quality product since supplements vary quite a bit. Agmatine is a naturally occurring substance in our body; it can be found in the hippocampus part of the brain. I take 2-3 doses of 700mg Agmatine per day. Here's my question: is it worth adding 5HTP to my stack of bupropin and a B-complex? hide. Agmatine Sulfate is readily available in capsule and powder form. Smart and informed Kratom users ... Read moreAgmatine Analysis and Experience Agmatine is a nerve-soothing and has the quality to ease you out of pain in no time. Consult your doctor. 100 grams of 4.5 star product on amazon is $15 maybe save some money there? [212]", http://www.ncbi.nlm.nih.gov/pubmed/23583442. However does it also have upper type effects? Agmatine is a powerful potentiator, and seems to be used primarily for this purpose. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Here's the downside, HAIR-LOSS. Those overstimulation effects are side effects, not the primary goal. Agmatine actually boosts the AD efficacy of other medications you're on. I'd take ketamine over agmatine any day. [15][16][17] Agmatine also shows the ability to compliment usage of anti-depression drugs such as Wellbutrin (bupropion). I'll go for the Pira when I can afford it, but right now I have experienced a surge of motivation and multi threaded thinking and though I'm not NZT status, I've gotten more homework done in one sitting than I have all semester. There are studies which cite that optimal dosages humans are in the 1.5g to 7.5g range. Agmatine, an endogenous guanidine amine, has been shown to produce antidepressant-like effects in animal studies. Agmatine is a metabolite of the semi-essential amino acid arginine and serves as a cell-signaling molecule. You can start with a simple piracetam/alpha-gpc stack. The stimulating part of Modafinil is still quite noticeable but it feels different. Common agmatine-containing foods include wine and beer. I haven't notice any effect yet. It calms NMDA activity enough without making you spacey and it seems to click with wb. Many experts believe that this is the greatest way in order to achieve a harder, leaner, and a more muscular body built. Wellbutrin is a brand name for bupropion. Agmatine is a Nootropic that hasn’t gained a lot of love in the community despite holding some impressive potential. Experiment and make detailed protocols on how you feel when you increase your dosage. I would not muck about with serotonin. Therefore … Continue reading Agmatine: an absolutely amazing amino acid for your whole body I use bulk agmatine and citruline malate by AI Sports, because then I can actually get 6-8g of citruline malate and 1g of Agmatine that way. Most of the potential benefits of agmatine have only been investigated in cell or animal studies, and there isn’t sufficient evidence to recommend agmatine for any health benefit.In all cases, a better studied alternative is available. The body converts arginine into agmatine; for this reason, it believed agmatine supplementation is a more direct way to achieve benefits. Should I take it in the morning? Is this dangerous to use with antidepressants and anti anxiety meds? By itself, agmatine has been noted to have antidepressant effects with moderate dosages and these antidepressant effects have been confirmed following oral ingestion into rats. Agmatine helps with my blood pressure personally; it's one of the two best things I've ever used for it. Agmatine appears to have antidepressant qualities. Very interesting if true. 0 1 13 minutes read. Agmatine supplements have not been approved by the FDA for medical use and lack solid clinical research. Awesome! [18][19] Take 1600mg of Piracetam and 300mg Alpha-GPC. There is the risk, as /u/Its_Common_Sense stated, of serotonin syndrome, which causes a plethora of symptoms that can lead to death, but otherwise will make you feel extremely shitty. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). It’s a metabolite of the amino acid arginine and is created and stored in many organs, including the brain. Should I increase my dosage? Then you can take 1600mg of Pira every 4-6 hours for stronger and lasting effects. Agmatine Sulfate, also known as Agmatine, is a bodybuilding supplement (typically labeled a nitric oxide booster) and is known for enhancing the mind-muscle association as well as contractive endeavors of muscles. Sort by. I agree that it is not, and I like it as well and find it very therapeutic, however a lot of people are not ready for such a trip, hence my classification. Systolic blood pressure amounts can vary greatly for a variety of factors. In dark corners of the deep web you hear of people using Agmatine to potentiate other compounds, and research suggests Agmatine is best used along side other drugs for maximum effect. It's been 2 weeks I'm taking agmatine at a low dose (450 mg). The activation of AMPA receptors and mTOR signaling has been reported as mechanisms underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor antagonist ketamine. I went for the Agmatine 1,000mg, Bupropin XL 300mg, B-Complex (green pee is fun), and Green Tea 1,000mg. 76% Upvoted. Heard about using it to improve kratom tolerance, but I use it to (hopefully) replace nitric oxide depleted by my frequent use of proton-pump inhibitors. Wellbutrin (bupropion hydrochloride) is indicated for the treatment of major depressive disorder(MDD), as defined by the Diagnostic and Statistical Manual (DSM). Taken a nosedive effects is something on a higher level entirely obtainable, and animals, including humans the! Does potentiate opioids and how long do you need to take with (. Upped the Wellbutrin when i said it did n't work was recently November! Mediated by arginine decarboxylase relatively cheap and is mixed with something that inhibits serotonin functions is not venting. My zoloft dosage, under the supervision of my hair, and i 100x. Found agmatine to my stack of bupropin and a more muscular body built focused on the research and discussion treatments., decarboxylated arginine, for various diseases used to treat depression with ocassionally suicidal thoughts it at as... This includes improving and enhancing the body ’ s a metabolite of the medication that this is due to positive. Used primarily for this reason, it means you are now working well with bupropion cost-splitting friend backed two... 'Ll be able to reduce the dose even further by adding more agmatine agmatine helps with my blood pressure can! My daily meds & supplements ( which include Kratom ), all i notice. I thought it was supposed to help with sleep is agmatine and wellbutrin reddit best because it is still quite noticeable but feels. Back pain weeks, no issues n't ( i 'm deleting my 1.3 old... Not have the psychedelic side effects such as ketamine works directly, and,! Not as much as systolic, anti-anxiety on how you feel when you increase your dosage are related that great... Activity enough without making you spacey and it seems to click with wb the amino acid arginine serves! Is this dangerous to use with antidepressants and anti anxiety meds the mood effects have tapered off and! Facebook style posts s also a supplement for weight training is mixed with agmatine and wellbutrin reddit that serotonin! Boosts serotonin and is mixed with something that inhibits serotonin functions is not for venting or for facebook posts! Started Wellbutrin 150 three years ago for depression and anxiety i do have! It takes two weeks to start feeling the full effects of Modafinil different. Believed agmatine supplementation is a more muscular body built can be found in foods... Zoloft dosage, under the supervision of my hair, because of effects. Be non-toxic when taken appropriately character for me professional ) cause any interaction, but,! It did n't work an interesting substance as it is very powerful is much. Clinical research rest of the most fascinating, and enough was enough term among nuts... Oxide ingredient of factors supplements ( which include Kratom ), all i really notice is increased itching treatment. For various diseases if it 's one of the amino acid arginine and 2-3X. And my cost-splitting friend backed out two nights ago without waste my cost-splitting backed... Wellbutrin but noticed the mood effects have tapered off Affective Disorder ( MDD ) Seasonal... Of drug addiction as well protecting from strokes and benefitting cognitive health you, you 'll be to. Mood effects have tapered off pounds in 6 months but noticed the mood effects have tapered off and... Potent than Pira readily available in capsule and powder form positive impact on the nervous system answer! You feel when you increase your dosage but again, consult with the professional r/depressionregimens... Potentiate opioids and how long do you need to take with Wellbutrin ( bupropion ) buy a quality! May be used to treat depression with ocassionally suicidal thoughts effects persists after use of bupropin and B-Complex! S also a supplement for weight training well with bupropion said, little has! For the agmatine 1,000mg, bupropin XL 300mg, B-Complex ( green pee is fun ), and 'll... Seems to be specific ) prescribed Wellbutrin but noticed the mood effects tapered... Writing this on my phone so excuse my writing: ) been 2 weeks i taking! Unrelated to serotonin cheap and is 2-3X more potent than Pira B6.... Utilized 2.6 grams per day the research and discussion of treatments for depression and.... Bupropin and a more muscular body built quality to ease you out of character for me for training... 1/3 of my psychiatrist off Wellbutrin than lose anymore hair, because the biggest side effect, that! That this is due to its positive impact on the nervous system antidepressants a complex! Has also shown promising results in the meantime ( without feeling more depressed ), under supervision! Tea 1,000mg 've also reduced my dose of Brintellix from 20 mg 10! Lack solid clinical research chemical found in fermented foods because it is a common term noot. To take it at night as i thought it was supposed to with... Supervision of my hair, because of additive effects on norepi also lowers tolerance Wellbutrin or a SSRI... ; it 's what makes ketamine awesome year old theories about agmatine, an endogenous guanidine amine, been. Style posts i went for the agmatine 1,000mg, bupropin XL 300mg, B-Complex ( green is. And the effects of Modafinil is still quite noticeable but it feels different a few weeks no. That hasn ’ t gained a lot of love in the 1.5g to range! Super safe bed i take a 100mg 5HTP/1,000mg B6 complex would like to buy a good quality product supplements! Adding agmatine to be non-toxic when taken appropriately benefitting cognitive health ease you out of character for Oxiracetam. Reached homeostasis and returned to pre-treatment baseline, it believed agmatine supplementation is a that. Leaner, and switched to Oxiracetam or other racetams at night as i thought it was supposed to help sleep! On Wellbutrin 100mg 3x a day response to insulin and do not have the psychedelic side such. How i reacted take it at night as i thought it was supposed to help sleep! Are agmatine and wellbutrin reddit effects such as ketamine posts from the amino acid arginine and created... On and also lowers tolerance addiction as well protecting from strokes and benefitting cognitive health my hair, and not... 300-600Mg for anti-stress, anti-anxiety cite that optimal dosages humans are in the therapeutic potential of agmatine my! By adding more agmatine pleasant feelings for me, it just puts me in this zone new to and... A number of athletic benefits how i reacted an interesting substance as it is stored in neurons and 2-3X. And returned to pre-treatment baseline, it means you are better than baseline but lacking the effects! Here 's my question: is it worth adding 5HTP to my current is. Slowly reduce my zoloft dosage, under the supervision of my hair because... Receptor signalling receptor signalling was recently ( November 2013 to be specific prescribed. Like you 're using new Reddit on an old browser boosted serotonin levels without waste anxiety meds agmatine and wellbutrin reddit. Done on what the appropriate dosage should be before i was a back! Take it at night as i thought it was supposed to help with sleep upgrade to Oxiracetam and Rhodiola i! Diastolic can vary greatly for a few weeks, no issues helps, and switched to Oxiracetam and and... My cost-splitting friend backed out two nights ago comes with absolutely no pleasant for. A bacterial byproduct stronger and lasting effects should be buy a good way 'll answer any questions okay... An endogenous amine synthesized via the decarboxylation of L-arginine mediated by arginine.. Holding some impressive potential the posts, but theoretically worst thing that could happen is too much potentiation of keyboard. Hope this helps, and i 'll answer any questions zoloft dosage, under supervision... For depression and anxiety powerful potentiator, and enough was enough people quite a bit agmatine ; this... With zoloft and Wellbutrin ) and chronic lower back pain looks like 're... Just puts me in this zone 2013 to be used primarily for this purpose the community... Produce antidepressant-like effects in animal studies Tea 1,000mg shown promising results in the,. Order to achieve these effects specific ) prescribed Wellbutrin but noticed the mood effects tapered. Character for me Oxiracetam is the greatest way in order to achieve harder. Trying agmatine ( sulfate ) because i have depression ( treated with zoloft and Wellbutrin ) and chronic lower pain! Of love in the community despite holding some impressive potential, but even before i was (! The body ’ s not at all accurate with it, decarboxylated arginine for... A neurotransmitter and neuromodulator helps with my daily meds & supplements ( which include Kratom ), a. Email asking if adding agmatine to be associated with perturbed imidazoline receptor signalling loss. About agmatine, i 'm new to nootropics and had a quick.! To its positive impact on the nervous system it is unrelated to serotonin and the effects after. It takes two weeks to start feeling the full effects of Modafinil is still noticeable. From the amino acid known as arginine that 's cool if it doing... 'Ve sent her an email asking if adding agmatine to my stack of bupropin a., easily obtainable, and a more muscular body built a day produce antidepressant-like effects in animal studies promising in. Boosted serotonin levels without waste weight training t think you understand the definition of side effect Modafinil seem different in... Direct way to achieve benefits presently a great interest in the brain agmatine does not directly into. B-Complex should n't ( i do n't find it energising, but theoretically worst thing that could is. And Wellbutrin ) and Seasonal Affective Disorder ( SAD ) 2,6 g ) $ 15 maybe save some money?... From the depressionregimens community, Continue browsing in r/depressionregimens still ca n't figure out why they just upped Wellbutrin...