Reactome i: R-SPO-1483191, Synthesis of PC R-SPO-1483213, Synthesis of PE R-SPO-4419969, Depolymerisation of the Nuclear Lamina R-SPO-75109, Triglyceride biosynthesis: Names & Taxonomy i. Hereditas (2020) 157:15 Page 2 of 9. Triglyceride biosynthesis: Resource: Reactome Genes: GK MOGAT1 AGMO GK2 DGAT2 LPIN1 LPIN2 GPAM MOGAT2 DGAT1 LPIN3 MOGAT3 GPAT2 GK3P: Size: 14 Equivalent Pathways. Triglyceride Biosynthesis Gene Set. D pathway: Pathway Genes. It was ascribed to the overlap of a triglyceride term (Reactome triglyceride biosynthesis) with three phospholipid terms (Reactome synthesis of PA, Reactome glycerophospholipid biosynthesis, and Reactome phospholipid metabolism) (MM = 0.48–0.5). ab100578; Abcam, Cambridge, MA) and triglyceride quantification kit (catalog no. A central part in this regulation is played by hormone-sensitive lipase (HSL), a neutral lipase abundant in adipocytes and skeletal and cardiac muscle, but also abundant in ovarian and adrenal tissue, where it mediates cholesterol ester hydrolysis, yielding cholesterol for steroid biosynthesis. Complete information for ELOVL1 gene (protein-coding), ELOVL fatty acid elongase 1, including: function, proteins, disorders, pathways, orthologs, and expression. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Triglyceride Biosynthesis Pyrimidine salvage reactions Circadian Clock Circadian rhythm Bmal1:Clock,Npas2 activates circadian gene expression Rora activates gene expression genotype WT KEGG and Reactome Circadian rhythm 2 4 6 Cry1 Nr1d1 Per1 Fbxl3 Npas2 Rorc Per3 Clock Bhlhe40 Bhlhe41 Arntl Per2 Cry2 Cholesterol biosynthesis 2 Mvd Sqle Pmvk Nsdhl Sc4mol Lss Mvk Dhcr7 … reactome_lipid_digestion_ mobilization_and_transpor… 59 go_low_density_ lipoprotein_particle_clearance 85 reactome_triglyceride_ biosynthesis 48 go_brown_fat_cell_ differentiation 83 kegg_adipocytokine_signaling_ pathway 42 go_positive_regulation_ of_lipid_storage 81 reactome_fatty_acid_ triacylglycerol_and_ketone_bod… 32 975 38 528 325 9217 2.5999999999999999e-2 1.9000000000000001e-5 Vit. Reactome analysis revealed that the top hits enriched in WTE-induced DEGs included cholesterol biosynthesis, regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor-binding proteins (IGFBPs), triglyceride biosynthesis, interleukin (IL)-6-type cytokine receptor ligand interactions, and glycolysis (Fig. REACTOME ION TRANSPORT BY P TYPE ATPASES: Genes involved in Ion transport by P-type ATPases: 0.0: 1.6: REACTOME MRNA 3 END PROCESSING: Genes involved in mRNA 3'-end processing: 0.0: 0.7: REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS: Genes involved in Synthesis of very long-chain fatty acyl-CoAs: 0.0: 0.8: REACTOME TRIGLYCERIDE BIOSYNTHESIS Biosynthesis of A2E, implicated in retinal degradation Gene Set. 975 12 528 40 9217 1.9e-3 1.3999999999999999e-6. ORF Names: SPAC1952.13. Plays important roles in controlling the metabolism of fatty acids at different levels. Organism i: Schizosaccharomyces pombe (strain 972 / ATCC … The Reactome definition of a 'reaction' includes many events in biology that are changes in state, such as binding, activation, translocation and degradation, in addition to classical biochemical reactions. Reactome is an open source and open access resource, available to anyone and covered by two Creative Commons licenses: the terms of the Creative Commons Public Domain (CC0) License apply to all Reactome annotation files, e.g. IF NOT reactome G alpha Q signaling events AND NOT reactome triglyceride biosynthesis AND NOT reactome amine compound SLC transporters: Meta = kegg, inv = N, s = 4, p = Inf: 9: 0.712: 0.906: 0.481: Group A: IF NOT kegg inositol phosphate metabolism AND NOT kegg amyotrophic lateral sclerosis ALS AND NOT kegg long term potentiation AND NOT kegg butanoate metabolism : Meta = … 1C). The 14 overlapping genes were general synthesis related genes (e.g., AGPAT/GPAT family, GPAM, and GPD1) that are involved in both triglyceride … 975 25 528 168 9217 1.2999999999999999e-2 9.5999999999999996e-6. The Reactome Pathway Database is a curated database of pathways and reactions (pathway steps) in human biology. The insulin and triglyceride levels were measured in the blood of the offspring euthanized on PNW20 using the insulin enzyme-linked immunosorbent assay kit (catalog no. proteins participating in the Triglyceride Biosynthesis pathway from the Reactome Pathways dataset. Standard name: REACTOME_TRIGLYCERIDE_BIOSYNTHESIS: Systematic name: M619: Brief description: Triglyceride biosynthesis: Full description or abstract : Collection REACTOME_TRIGLYCERIDE_BIOSYNTHESIS: Reactome: 2.24* PYRUVATE_METABOLISM: Gene ontology: 2.24* KEGG_VALINE_LEUCONE_AND_ISOLEUCINE_DEGRADATION: KEGG: 2.16* STEROID_BIOSYNTHETIC_PROCESS: Gene ontology: 2.11* KEGG_STARCH_AND_SUCROSE_METABOLISM: KEGG: 2.08* PROTEASOME_COMPLEX: Gene … 42 proteins participating in the Triglyceride Biosynthesis pathway from the Reactome Pathways dataset. Both black and purple wheats reduce total cholesterol, triglyceride, and free fatty acid levels in serum, with the restoration of blood glucose and insulin resistance. However, causality has been questioned, as … High-density lipoproteins (HDLs) and low-density lipoproteins (LDLs) and very-low-density lipoproteins (VLDLs) … No significant changes in plasma triglycerides, basal plasma glucose, serum free testosterone, or plasma FFA levels were observed. more... References: Biosynthesis of triacylglycerols Prog Lipid Res 35:169-201 . Reactome is an open source and open access resource, available to anyone and covered by two Creative Commons licenses: the terms of the Creative Commons Public Domain (CC0) License apply to all Reactome annotation files, e.g. Our previous study has reported th… Per- and polyfluoroalkyl substances (PFASs) are omnipresent in the environment, food chain, and humans. S5). Pathway analysis suggested that these enzymes function in glucose metabolism pathways including glycolysis, gluconeogenesis and glycogen storage, as well as lipid metabolism pathways including fatty acid and triglyceride biosynthesis (Supplementary Fig. Reactome_ ID Reactome Pathway 75,109 Triglyceride Biosynthesis 163,560 Hormone-sensitivelipase (HSL)-mediated triacylglycerol hydrolysis 535,734 Fatty acid, triacylglycerol, and ketone body metabolism 1,266,738 Developmental Biology, 381,340 Transcriptional regulation of white adipocyte differentiation Jiang et al. Epidemiological studies have shown a positive association between serum levels of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), and increased serum cholesterol and, in some cases, also triglyceride levels. Black wheat significantly elevates the expression of enzymes related to fatty acid balancing, β‐oxidation, and oxidative stress that supported the biochemical and physiological positive outcomes. Compendia expression profiles : GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): Advanced query: Further investigate these 105 genes : Gene families : Categorize these 105 genes by gene family : Show members (show 105 members mapped to 105 genes) Protein names i: Recommended name: Nuclear elongation and deformation protein 1. GeneCards - The Human Gene Compendium The most represented Reactome pathways included: muscle contraction, triglyceride biosynthesis, and collagen degradation (Table 1). Gene names i: Name:ned1. reactome_biosynthesis_of_epa_derive d_spms reactome_biosynthesis_of_maresin_li ke_spms reactome_biosynthesis_of_maresins reactome_biosynthesis_of_specialize d_proresolving_mediators_spms_ reactome_biosynthesis_of_the_n_glyc an_precursor_dolichol_lipid_linked_ oligosaccharide_llo_and_transfer_to _a_nascent_protein reactome… reactome_biosynthesis_of_epa_derive d_spms reactome_biosynthesis_of_maresin_li ke_spms reactome_biosynthesis_of_maresins reactome_biosynthesis_of_specialize d_proresolving_mediators_spms_ reactome_biosynthesis_of_the_n_glyc an_precursor_dolichol_lipid_linked_ oligosaccharide_llo_and_transfer_to _a_nascent_protein reactome… proteins participating in the Biosynthesis of A2E, implicated in retinal degradation pathway from the Reactome Pathways dataset. Jump to: navigation, search. The list of genes included in the most represented Reactome pathways was compared to clustering results and the majority, 31 … 1 ACP-SH acyl-ACP ACP-SH triacylglycerol Lecithins phosphoryl-choline phosphatidic acid H2O 1,2-diacylglycerol CMP H2O 1,2-diacylglycerol 1-acylglycerol-3-phosphate acyl-ACP glycerol-3-phosphate phosphatidylcholine CPT1 SLC1 ISC1 DGA1 CDP-choline acyl-CoA phosphate Coenzyme A. The overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of phosphatidic acid to diacylglycerol, and conversion fo diacylglycerol to triacylglycerol. Compendia expression profiles : GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): Advanced query: Further investigate these 200 genes : Gene families : Categorize these 200 genes by gene family : Show members (show 200 members mapped to 200 genes) ab65336; Abcam), respectively. Steroid Biosynthesis (general overview) Pathway: WP496 (WikiPathways) VLDL: Metabolite: CHEBI:39027 (ChEBI) Very low-density lipoprotein (VLDL) is one of the two main TG (triglyceride or triacylglycerol) carrying lipoproteins, which are spheroidal macromolecular complexes responsible for transporting lipids through plasma. 5% weight loss resulted in a 2% ± 2% decrease in fat-free mass (FFM), an 8% ± 3% decrease in body fat mass, a 7% ± 12% decrease in intra-abdominal adipose tissue (IAAT) volume, and a 40% ± 21% decrease in intrahepatic triglyceride (IHTG) content (). From Reactome Pathways. Triglyceride Biosynthesis (Saccharomyces cerevisiae) From WikiPathways. Gene Set 430 : REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Number of genes: 17666 (in list), 38 (in gene set) Gene List Index Running Enrichment Score (RES) "clus6" "NON.clus6" Peak at 2282 Zero crossing at 9532 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.0 0.5 1.0 1.5 2.0 2.5 3.0 Gene Set Null Distribution ES = 0.519 NES = 1.72 Nom. Salidroside is a kind of phenylethanoid glycoside and widespread in the plants from Rhodiola and Ligustrum species. … From Reactome Pathways. 4 Reactome Pathways for LPIN1 ... Triglyceride Biosynthesis: Synthesis of PC: 3 Kegg Pathways (Kegg details for LPIN1): Glycerolipid metabolism: Glycerophospholipid metabolism: Metabolic pathways Pathway & Disease-focused RT 2 Profiler PCR Array including LPIN1: PPAR Targets in human mouse rat: Interactions: GeneGlobe Interaction Network for LPIN1 STRING Interaction Network Preview (showing … Standard name: REACTOME_CHOLESTEROL_BIOSYNTHESIS: Systematic name: M16227: Brief description: Cholesterol biosynthesis: Full description or abstract : Collection